MTHFR Check (cheek swab)
As much as half of the population may have an MTHFR gene test mutation. MTHFR testing can provide valuable information about an individual's risk of health conditions associated with folate deficiency and elevated homocysteine levels.

What is an MTHFR mutation?

MTHFR is an enzyme that helps our body convert folate (a B vitamin found in many foods) into a form that can be used to regulate the levels of homocysteine in our blood. Homocysteine is an amino acid that can be harmful to our health when present in high levels. The MTHFR enzyme also plays a role in the production of an important molecule called SAM, which is needed for many biological processes in our body, including the production of neurotransmitters (chemicals that help our brain function).


Genetic variations in the MTHFR gene can result in altered enzyme activity, leading to lower levels of folate and higher levels of homocysteine in the body. MTHFR testing is a simple test that can identify genetic variations in the MTHFR gene. Individuals with MTHFR gene variations may benefit from personalised treatment strategies to optimise their folate and homocysteine levels. These strategies may include dietary modifications, supplementation with folic acid or other forms of folate, and medications that lower homocysteine levels.

What we test
MTHFR Mutations
Two relatively common DNA sequence variants known as single nucleotide polymorphisms (SNPs) are tested. These two MTHFR variants are called C677T and A1298C and individuals can inherit one or both variants. Please note if you are considering the myDNA Comprehensive Health Report or Genetic Methylation Test, this test is covered within that and does not need to be ordered separately.
This MTHFR gene test is a simple cheek swab test which measures:
Test instructions
Your test kit and all instructions are posted directly to you, and there is no need to visit a collection centre.
calendar-instructions instruction-kit
Results for this test available in 21-24 business days from being received at the lab and will be published in your online dashboard.
Ready. Set. Go!
for £115
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