Genetic Methylation Check - International Customers
The Genetic Methylation Check analyses your DNA to provide insights into your individual methylation pathways. Methylation is the process which allows your genes to function optimally, so understanding your personal methylation pathways is key to optimising your health.

This genetic methylation test covers 7 key methylation genes and is performed by a NATA-accredited laboratory in USA.

The regulation of methylation pathways is influenced by both genetic and environmental factors. Genes encoding enzymes like DNA methyltransferases play a crucial role in determining the DNA methylation pattern, affecting gene expression - whether genes are turned on or off. However, environmental factors such as diet, exposure to toxins, and stress also impact methylation patterns.


The simple cheek swab test will provide personalised insights into your health across the following categories:

  • Methylation
  • Homocysteine buildup
  • Folate intake requirements
  • Cognitive performance
  • Mental health
  • Gut health

A genetic strength and weaknesses report is provided with personalised nutrition and lifestyle recommendations to help you optimise your methylation pathways.

What we test
Genetic Variations of Note
Research indicates that specific genetic variations are associated with a higher likelihood of developing Alzheimer's disease, hemochromatosis, or celiac disease. These conditions are prevalent among individuals with certain genotypes, highlighting the importance of understanding genetic predispositions in disease susceptibility.
Homocysteine Buildup
This test includes the MTHFR, MTRR, MTR, MTHFD1, and CBS genes, each of which plays an important role in the methylation cycle. This cycle is responsible for converting homocysteine into methionine or glutathione with the aid of folate, vitamin B12, and B6. Mutations within methylation genes may reduce the functionality of the enzymes produced, impacting how well they can do their job. These key genes in the methylation pathway work to break down homocysteine, an inflammatory compound that is normally only present in the blood in very small amounts. Homocysteine buildup in the bloodstream is like clogging a pipe in a plumbing system; it obstructs normal flow and increases inflammation, potentially leading to cardiovascular disease, neurodegenerative disorders, digestive issues, and complications during pregnancy. Understanding these genetic variations can offer valuable insights into individual health risks, empowering informed decisions for better health management.
Active Folate Deficiency
This test includes the MTHFR, MTHFD1, MTR and MTRR genes to determine how variations in your genetics may influence your folate intake needs. Folate is a B vitamin that is essential for DNA synthesis and methylation. Folate deficiency disrupts these processes, leading to impaired cell division and increased levels of homocysteine. This can result in neural tube defects in newborns, increased risk of cardiovascular disease, and potential cognitive impairments. Understanding these genetic variations can offer valuable insights into individual health risks, empowering informed decisions for better health management.
Cognitive Performance & Mental Wellbeing
This test focuses on two important genes linked to how our brain functions and our overall mental well-being, called COMT and PEMT. The COMT gene affects how our brain breaks down a chemical called dopamine, which plays a big role in how we feel happy and motivated. Think of dopamine as the brain's 'feel-good' messenger, involved in memory, motivation, and pleasure. Changes in how our body handles dopamine can impact things like problem-solving skills, memory, and coordination. If your body breaks down dopamine efficiently, you might find you're sharper in these areas. But if there are mutations in COMT, it can affect your mood and how well your brain works. The PEMT gene helps make something called phosphatidylcholine, which is important for building cell membranes in our body and for brain function. Changes in this gene can affect how well it makes phosphatidylcholine, which in turn can affect how well your liver and brain work. It might also influence your sleep and make you more prone to certain health issues like fatty liver disease and heart problems. Understanding these genetic differences can give us valuable clues about our brain health and overall well-being. This knowledge helps us make better decisions about how to take care of our health.
Gut Health
This test focuses on mutations in the MTR gene, which can provide insights into your gut health, particularly concerning inflammatory bowel conditions and their associated symptoms. Inflammatory bowel disease (IBD) encompasses a range of inflammatory conditions affecting the colon and small intestine, such as Crohn’s disease (CD) and ulcerative colitis (UC). These conditions often lead to symptoms like abdominal pain, bloating, and diarrhoea. Some research has shown that carrying two variants in the MTR gene can lead to a 48% higher risk for IBD compared to the standard genetic makeup. Understanding these genetic variations can provide valuable insights into your individual risk factors for IBD and related symptoms.
Test instructions
Your test kit and all instructions are posted directly to you, and there is no need to visit a collection centre.
Mail your sample back to the lab using the prepaid envelope and packaging.
calendar-instructions instruction-kit
Results for this test available in 21-24 business days from being received at the lab and will be published in your online dashboard.
Ready. Set. Go!
for £245